Application Quantum Physics on Bone Imaging 2019

Ali Ghasem-Zadeh

Depts of Endocrinology and Medicine, Austin Health The University of Melbourne Australia

Cortical porosity measurement, a challenging task:

HR-pQCT 100 µm spatial resolution in-vivo imaging 

• Cortical pores ~40 to 100 µm, osteocyte lacunae (~10 to 30 µm), and canaliculi (~0.1 µm)
• Locating low density and small objects (pores, ~ 0 mgHA/cm³) in the relatively large  and very high-density background (bone tissue >1000 mgHA/cm³)                      

• Cortical pores ~40 to 100 µm, osteocyte lacunae (~10 to 30 µm), and canaliculi (~0.1 µm)
• Locating low density and small objects (pores, ~ 0 mgHA/cm³) in the relatively large  and very high-density background (bone tissue >1000 mgHA/cm³)                       

• Beam hardening effects associated with poly-energetic x-ray spectrum
• Larger point spread function in consequence of cone beam x-ray             

Australian Synchrotron Radiation

• Monochromatic x-ray free of beam hardening
• Higher rate of beam flux from 6 to 120 keV
• Capability of scanning large objects with a greater scanning field of view
• Coherent and parallel beam